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Production of 3D Tissue Engineering Structure with Appropriate Biological Properties in Iran

News Date : 2016-09-01 Visit : 479

Iranian researchers synthesized a scaffold with better properties in comparison with similar samples to be used in tissue engineering

TEHRAN (INIC)- Iranian researchers from Amirkabir University of Technology produced a scaffold with better properties in comparison with similar samples to be used in tissue engineering.


Although scientists have been able to culture cells outside the body for years, the technology to grow complicated and three-dimensional networks have recently been developed to be replaced with the damaged tissue.


According to the definition, a scaffold should be designed with appropriate physical properties with the ability for the cells to stick to it, cellular migration, proliferation and distinguish to produce a tissue through engineering methods.


The aim of this research was to produce a three-dimensional scaffold with appropriate microstructure and biological properties by using polymeric nanofibers in a way that the produced scaffold has higher efficiency and biocompatibility than similar products.


Nanofibers have been designed in this research in a three-dimensional manner. This fact significantly increases electrical conductivity of the scaffold, to the extent that they present much higher cellular migration in comparison with the two-dimensional product. Modified electrospinning process was first designed in this research. Then, optimum conditions were determined for the synthesis of three-dimensional nanofibers. The scaffold was produced next by using polyaniline/polycaprolactone solution. Finally, the produced structure was investigated from structural and biological points of view.


Observations showed that when the concentration of polyaniline reaches 70% from 7%, fibers convert from two-dimensional phase to three-dimensional, and electrical conductivity increases 1,000 times.